Abstract : HR-MAS (High Resolution Magic Angle spinning) NMR (Nuclear Magnetic Resonance) is a technology which combines the advantages of both solid- and liquid-state NMR by allowing to concomitantly measure intact and non-manipulated samples. Based on both 1D and 2D homo- and heteronuclear NMR spectra, HRMAS evaluates the composition of fresh semi-solid samples with a similar resolution as that of classical liquid-state NMR techniques. The enhanced spectral quality still obtained for semi-solid samples is mainly due to the MAS system, whose rapid spinning and sample orientation minimize the anisotropic processes that prevent the acquisition of meaningful NMR spectra for non-liquid materials. The HRMAS NMR has also showed promising results in identifying biomarkers in different diseases. Although few physical variables may effect the spectral quality and data. Therefore, in this chapter we will discuss those factors for efficient data acquisition.
Cite : Srivastava, S., & Roy, R. (2022). Hrmas (High Resolution Magic Angle Spinning) Nmr (Nuclear Magnetic Resonance) Spectroscopy And Effect Of Physical Variables (1st ed., p. 27). Global Research Foundation. https://doi.org/10.52458/9789391842741.2022.eb.grf.asu.ch-06
