Abstract : The tissue biopsies have always been widely studied for the identification of pathology associated with it especially in case of cancer or chronic inflammations. The quantum of information a tissue biopsy carries in itself has been immense and therefore, it is an extensively explored biological sample at genetic, proteomic and nowadays at metabolic level. In metabonomics, the tissues are either subjected to extraction procedures or are analysed directly by HRMAS NMR spectroscopy. MAS has an added advantage of maintaining tissue integrity for other genomic and mRNA studies from the same tissue biopsies. Moreover, minimal sample preparation has led to numerous biomedical applications for investigation of breast cancer affected tissue biopsies (Sitter, Sonnewald et al. 2002), brain tumors (Cheng, Chang et al. 1998; Warren 2004), liver transplants (Duarte, Stanley et al. 2005), prostate cancer (Taylor, Wu et al. 2003; Santos, Kurhanewicz et al. 2010; Dittrich, Kurth et al. 2012), rat intestine development (Wang, Tang et al. 2005) and many more studies including toxicological effects on tissues and its biochemical characterisation (Wang, Bollard et al. 2006).
Keywords : TISSUE, METABOLOMICS
Cite : Srivastava, S., & Roy, R. (2022). Tissue Metabolomics (1st ed., p. 24). Global Research Foundation. https://doi.org/10.52458/9789391842741.2022.eb.grf.asu.ch-05
