Abstract : Urine is highly non-invasive in nature as compared to other bio-fluids and is very popular for metabonomic analysis due to its ease of availablity. It has been a powerful tool for probing the metabolic responses under different stresses like chemical induced toxicity(Holmes, Bonner et al. 1992; Holmes, Sweatman et al. 1995; Holmes, Loo et al. 2007), cancer (Carrola, Rocha et al. 2010; Srivastava, Roy et al. 2010), inborn errors of metabolism (Holmes, Foxall et al. 1997) and nutritional interventions(Lenz, Bright et al. 2004; Edmands, Beckonert et al. 2011). Many studies have documented the effect of sample handling has upon the metabolic make-up of urine. Different methods of sample preparation and sample storage (room temperature (22°C), refrigerator (4 °C), or the deep-freeze -80°C have significant effect upon the changes of urine metabolites over time, as detected by 1H-NMR.
Cite : Srivastava, S., & Roy, R. (2022). Variables In Urine Metabolomics (1st ed., p. 17). Global Research Foundation. https://doi.org/10.52458/9789391842741.2022.eb.grf.asu.ch-04
